A Review on Novel Approach of Bilayer Technology
B. Mahesh Kumar*, P. Vishnu, A. Pratyusha, V. Uma Maheswara Rao
In modern era bi-layer tablet is for successful development of immediate and modified drug delivery system for various diseases and disorders. Bilayer tablets have been developed to achieve modified release of drug. The primary objective of bi-layer tablet is to avoid chemical incompatibilities between APIs by physical separation and to develop different drug release profiles (immediate release and modified release). In bi-layer tablet the immediate release layer act as the loading dose and modified release layer act as the maintenance dose. To produce a good quality bilayer tablet, the machinery should be constructed as per GMP. Various machineries are available to overcome common bi-layer problems, such as layer separation, insufficient hardness, inaccurate individual weight control, cross contamination between the layers etc. In this review we focus on the different types of press techniques, how to solve problems of bi-layer tablet.
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