Analytical Techniques by Mass spectrophotometry for the Estimation of Mirtazapinein Bulk and Pharmaceutical Dosage Forms: A Review
P. Sridhar*, C. Radhika, A. Ajitha, V. Uma Maheswara Rao
Mirtazapine (MRZ) has a piperazinoazepine structure1,2,3,4,10,14bhexahydro- 2- methylpyrazino [2,1-a]-pyrido [2,3-c] benzazepine}. It belongs to the class of noradrenergic and specific serotonergic inhibitor antidepressants (NaSSA). MRZ increases the central noradrenergic an serotonergic activity by blocking α2 adrenergic receptors. MRZ also acts as an antagonist of postsynaptic serotonin type 2 (5-HT2) and type 3 (5- HT3) drug has a different mechanism compared to most of the second generation antidepressants, and it is used to treat generalized anxiety , obsessive–compulsive , and post traumatic stress disorders . It has a high affinity for histamine H1 receptors: Literature survey reveals that Mirtazapine is estimated by Mass spectrometry.
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