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Assessment of Serum Paraoxonase Levels In Patients Fatty Liver Disease

Abstract

Ramanujam Singh*, Guria Kumari

The liver plays a key role in the synthesis of serum Paraoxonase (PON). It is circulating enzyme in the serum and bound to HDL. PON has function as an anti-oxidant effective of protecting low density lipoproteins against peroxidative reactions. PON1 levels have been reported in a variety of diseases along with the liver diseases. The study was planned with the aim of ascertaining the diagnostic use of level of the PON in various diseases. The two group of patients were selected based as Fatty Liver disease patients and control group patients. The blood samples were withdrawn from the patients. The various biochemical parameters such as fasting blood glucose, lipid profiles, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) levels were reposted in the two groups of the patients. The study has established PON levels were declined in patients with fatty liver disease. With the specificity and sensitivity of this enzyme being high, it could emerge as a parameter to assess liver function.

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