Biological Activity of Pyrimidine Derivatives | Abstract

Asian Journal of Pharmaceutical Technology and Innovation (ajpti)

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Biological Activity of Pyrimidine Derivatives


Sudha Singh *, Shamim Ahmad

Anti-inflammatory efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) has been related to their properties as inhibitors of cyclooxygenase (COX)-mediated prostaglandin (PG) synthesis. However, recent studies have suggested that variations of the in vivo antiinflammatory actions among different NSAIDs could not be solely explained by COX inhibition. Here, we have analyzed the effects on T cell activation of novel pyrazole derivatives. Pyrazoles represent a most active classes of compounds possessing a wide spectrum of biological activities. A systematic investigation of this class of heterocyclic lead revealed that pyrazole containing pharmacoactive agents play important role in medicinal chemistry. The prevalence of pyrazole cores in biologically active molecules has stimulated the need for elegant and efficient ways to make these heterocyclic lead. Pyrazole derivatives have a long history of application in agrochemicals and pharmaceutical industry as herbicides and active pharmaceuticals.

Share this article


tempobet giriş

tempobet giriş

agar io cappadocia tours cappadocia hotels cappadocia hotel cappadocia balloon cappadocia balloon flights

wormax io