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Comparative Analysis of Antimicrobial Activity of Three Cephalosporins on Clinical Isolates


Sylvester C. Ohadoma1*, Felix N. Osuala2

Objective: To compare in-vitro antimicrobial activity of commonly used cephalosporins against some Gram-positive and Gram-negative microorganisms. Material and methods: Clinical isolates were obtained from Madonna University Teaching Hospital, Elele, Rivers State, Nigeria, and were tested for antibiotic susceptibility using disc diffusion standard procedure. Result: Ceftriaxone gave the highest zone of inhibition value against Proteus specie (29.70 mm) and E. coli (25.50 mm), as compared to cefuroxime (15.60 mm and 12.00 mm), and Ceftadizime (21.00 mm and 14. 50 mm) respectively. There were however, differences in the zones of inhibition values of the three Cephalosporins with Staphylococcus aureus and Klebsiella pneumoniae. Conclusions: From the result obtained, ceftiaxone was the most effective antibiotic in inhibiting the growth of the four clinical isolates especially E. coli and Proteus specie, and hence could be used for treatment of resistant organisms where ceftadizime and cefuroxime have failed.

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