Development and Characterization of Emulgels For Treatment of Chronic Wounds.
Abstract
Ferreira, P.G.A,*; Souza, R.S.B; Costa, V.G.B; Ferreira, V.F.C; Cruz, R.C.C; Futuro, D.O.A
This study was conducted to develop an emulgel formulation for wound healing using Carbopol 940 as the gelling agent and isopropyl myristate as the oily phase. The prepared emulgels were evaluated regarding their rheological behavior and zeta potential. Accelerated stability analyses are a common approach for predicting the long-term stability of pharmaceutical formulations. Five formulations differing only in the proportions of the gel and emulsion were stored for 90 days under two different temperature-controlled conditions (-5 ºC ± 2 ºC/ 45 ºC ± 2 ºC). Zeta potential and rheology measurements indicated that formulations F2 and F3 showed better characteristics for use in treating chronic wounds. Stability analyses showed that the rheological behavior and zeta potential of all of the prepared emulgels remained unchanged during storage for 90 days. As a general conclusion, the results indicated that the emulgel formulations were successful concerning all of the parameters evaluated for wound healing.
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