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Development and Validation of a RP- HPLC Method for Quantitation of Oxcarbazepine in Tablet Dosage Form | Abstract

Asian Journal of Pharmaceutical Technology and Innovation (ajpti)

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Development and Validation of a RP- HPLC Method for Quantitation of Oxcarbazepine in Tablet Dosage Form

Abstract

Purva Singh*, Manish Kumar Gupta, Chakresh Kumar, Vijay Bhalla

A novel, accurate and precise HPLC method for determination of oxcarbazepine has been developed and validated. Separation was achieved on X Terra C18 column (50 x 4.6 mm internal diameter and 5μm particle size) using Ammonium Bicarbonate and Acetonitrile as a mobile phase at a flow rate of 1.0ml/min and photo diode array detection at 214nm. The developed method was applied for quantitative determination of above drugs in tablet dosage forms and the method was validated with respect to specificity, precision, linearity, accuracy, system suitability, robustness and solution stability. The method was linear over the range of 50-300ug/ml for Oxcarbazepine respectively. The mean recovery was found to be in the range of 99.01-99.28%. The percentage of relative standard deviation was found to be less than critical value. The method was found to be accurate, precise and selective for simultaneous estimation of Oxcarbazepine in tablets.

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