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Development and Validation RP-HPLC Method for Simultaneous Estimation of Telmisartan and Nifedipine In Synthetic Mixture | Abstract

Asian Journal of Pharmaceutical Technology and Innovation (ajpti)

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Development and Validation RP-HPLC Method for Simultaneous Estimation of Telmisartan and Nifedipine In Synthetic Mixture

Abstract

Zeel T. Doshi*, Jignesh S. Shah1, Dilip G. Maheshwari2

A simple, specific and accurate Reverse Phase High Performance Liquid Chromatography Method was developed for the simultaneous determination of Telmisartan and Nifedipine in Synthetic Mixture. The using Phenomenex Luna C18 (250 mm x 4.6 mm, 5 μm) column in Isocratic mode, with Mobile Phase containing ACN: Water: Methanol in the ratio of (10:20:70 v/v/v) pH 3.8 adjusted with Orthophosphoric acid at detection wavelength 234 nm with flow rate is 1 ml/min and run time is 15 min. the average retention time was found to b 2.563 min and 4.403 min for TEL and NIFE respectively. The calibration was linear in concentration range of 4-20 ð?????g/mL for TEL and 2-10 ð?????g/mL for NIFE. The low RSD (< 2%) Value indicates that the method is precise. The recoveries for TEL and NIFE were found to be in the range of 99-100%. The proposed method was Validated and successfully applied for the estimation of Telmisartan and Nifedipine in Synthetic Mixture.

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