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Development and Validation RP-HPLC Method for Simultaneous Estimation of Valsartan and Nifedipine in Synthetic Mixture | Abstract

Asian Journal of Pharmaceutical Technology and Innovation (ajpti)

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Development and Validation RP-HPLC Method for Simultaneous Estimation of Valsartan and Nifedipine in Synthetic Mixture

Abstract

Pankti M. Shah*, Jignesh S. Shah1, Dilip G. Maheshwari2

A simple, specific and accurate Reverse Phase High Performance Liquid Chromatography Method was developed for the simultaneous determination of Valsartan and Nifedipine in Synthetic Mixture. The using Phenomenex Luna C18 (250 mm x 4.6 mm, 5 μm) column in Isocratic mode, with Mobile Phase containing Methanol: Water: ACN (pH 3.7 adjusted with 10% Ortho Phosphoric Acid) (70:25:05 %v/v/v). The Flow Rate was 1 ml/min and effluents were monitored at 233 nm. The Retention Time of Valsartan and Nifedipine were found to be 8.003 min and 5.290 min respectively. The Linearity for Valsartan and Nifedipine were found to be 4-20 μg/ml and 1.5-7.5 μg/ml respectively. The Recoveries of Valsartan and Nifedipine were found to be 99.50% – 100.15% and 99.33% – 100.40% respectively. The proposed method was validated and successfully applied for the estimation of Valsartan and Nifedipine in Synthetic Mixture.

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