Evaluation of Diuretic Activity of Passiflora Nepalensis in Rats
S. Verma*1, D. Tripathi1
This study was conducted to investigate the diuretic potential of aqueous methanolic extract of Passiflora nepalensis in rats. The extract at doses of 10, 30 50 and 100 mg/kg was administered intraperitoneally in acute diuretic model. Furosemide (10 mg/kg i.p) was used as standard drug. Total urine volume and urinary excretion of electrolytes were measured. Preliminary phytochemical tests were also performed using standard procedures. The extract exhibited a significant dose dependent diuretic effect at all the doses when compared to control group. Urinary excretion of sodium was significantly increased by the extract while a significant increase in potassium excretion was only observed at higher doses. Phytochemical analysis illustrated that the extract contained compounds such as alkaloids, saponins, tannins, flavonoids, cardiac glycosides and reducing sugars. It is conceivable therefore that the aqueous methanolic extract of P. nepalensis contain certain biologically active compounds that might be responsible for the diuretic activity.
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