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Evaluation of Plasma Lactate and Electrolytes In Type II Diabetes Mellitus | Abstract

Asian Journal of Pharmaceutical Technology and Innovation (ajpti)

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Evaluation of Plasma Lactate and Electrolytes In Type II Diabetes Mellitus

Abstract

Narwade N B*1, Kolpe D V2, Udaykiran Bhalge3

Aim: To estimate sodium (Na+), potassium (K+) , bicarbonate (HCO3â????) and lactate levels in arterial blood of diabetes mellitus type II patients. Material and Method: 90 non-alcoholic, non-smoker subjects above the age of 40 years were participated in the present study, subdivided in 3 groups. Group 1: 30 diabetic subjects above the age of 40 years suffering from diabetes mellitus type II as diagnosed by the physician and having random plasma glucose < 400 mg/dl. Group 2 : 30 diabetic subjects above the age of 40 years suffering from diabetes mellitus type II as diagnosed by the physician and having random plasma glucose ≥ 400 mg/dl. Control group : 30 non-diabetic age and sex matched subjects. Arterial blood samples were collected from radial artery in a heparinised syringe & processed immediately on blood gas analyzer GEM PREMIER 3000, using GEM PREMIER 3000 pak cartridge. Results: There was significant decrease in plasma sodium levels in diabetic patients compared to controls. Plasma potassium levels were significantly increased in diabetic patients than controls. Conclusion: Uncontrolled hyperglycemia (group 2 diabetics) is significantly associated with electrolyte imbalance and lactic acidosis in type II diabetes mellitus patients. It was concluded that electrolyte imbalance found in diabetics may have great potential as a diagnostic tool in clinical practice and have a significant effect upon controlling the risk of many diseases & complications.

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