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Evaluation of the Effects of a Single Bolus of Erythropoietin on Reducing the Incidence of Atrial Fibrillation after Coronary Artery Bypass Graft Surgery; A Randomized, Double-Blind, Placebo-Control Study | Abstract

Asian Journal of Pharmaceutical Technology and Innovation (ajpti)

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Evaluation of the Effects of a Single Bolus of Erythropoietin on Reducing the Incidence of Atrial Fibrillation after Coronary Artery Bypass Graft Surgery; A Randomized, Double-Blind, Placebo-Control Study

Abstract

Shervin Ziabakhsh Tabary*, MD, FCTS

 Introduction: Atrial Fibrillation is the most common arrhythmia

developing after coronary artery bypass surgery. Many studies have been
done to reduce the incidence of post CABG AF. In our recent study we
used Indocid and showed that it can reduce the incidence of AF by
reducing the inflammatory reactions. In this study we want to understand
if we can reduce the incidence of post CABG AF with reducing the
ischemia during the cross-clamp time in CABG by a single bolus of
Erythropoietin.
Material and methods: 43 patients that were referred to Mazandaran
Heart Center (Sari, Iran) for elective CABG between September 2010 and
October 2011 were included in this study and randomly divided into two
groups :Erythropoietin group and control group. Patients in
Erythropoietin group were treated by common medical therapies and
CABG plus 700 IU/kg Erythropoietin (PD Poietin, puyeshdaroo, Iran),
intravenously infusion, exactly 5 min after termination of cross clamp: at
the start of reperfusion and patients in control group were treated by
common medical therapies and CABG surgery plus 10cc normal saline as
placebo.
Results: There was no significant differences between two control and
EPO group according to their age, sex ,involved vessels ,number of grafts,
cross-clamp and pump time. There was statistically lower incidence of
post CABG AF in EPO group.
Discussion: Showing that the incidence of post CABG AF has been
reduced by decreasing the cross-clamp time and therefore the ischemia
during surgery in our previous study, we planned this study to find that a
single bolus of Erythropoietin used in CABG can reduce the incidence of
post CABG AF by reducing the ischemia occurred by post perfusion injury.

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