Formulation and Characterization of Oral Suspension Containing Ibuprofen
Abstract
M. Sudhir*1, Ch. Divya2, N. Lakshmi Prasanti2, Sk. Liakhat Ali, Ch. Fridepaul, N.Jyothi2
The present work was aimed with the objective of formulating oral suspension of ibuprofen to enhance the convenience and compliance by the elderly and pediatric patients. The suspension were prepared by incorporating the prepared ibuprofen physical mixtures so as to achieve the aimed percent drug release (using poloxomer, Poly vinyl pyrrolidone (PVP and PolyVinaylAlcohol (PVA)) in sodium carboxy methyl cellulose as dispersing medium. Particular attention was given to the selection of the suitable taste masking agents. The suspension was characterized in term of ibuprofen content, viscosity, and sedimentation volume and dissolution test. The promising suspension F8 having the optimal formula showing the greatest dissolution and satisfactory sedimentation volume and physico-mechanical properties compared with a reference marketed product. FT-IR studies revealed that there is no interaction between the drug and the polymers used in the study. Rheological studies revealed significant difference between the suspensions that the incorporation of PVP and PVA enhances the viscosity of the suspension as a result the rate of dissolution was retarded.
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