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Formulation and Evaluation of Cefpodoxime Proxetil Solid Dispersion: An Approach for Dissolution Enhancement of Cephalosporin

Abstract

Kashish Aziz*1, Babar Iqbal1, Azim Akhtar2, Kanchan Kohli1, Sanjula Baboota1, Abdul Mateen2

Cefpodoxime Proxetil is an broad spectrum, third generation cephalosporin drug used in the treatment of skin infections, upper respiratory tract and urinary tract infections. Furthermore it shows low aqueous solubility, poor dissolution and hence low oral bioavailability. In present study an attempt has been made to enhance the aqueous solubility of Cefpodoxime Proxetil and hence its availability in aqueous media. Solid dispersion (SD) of Cefpodoxime Proxetil using soluplus as carrier was prepared by solvent evaporation method. The prepared solid dispersion was characterized using FTIR, SEM, DSC and evaluated for In vitro drug release. FTIR and DSC results indicated chemical compatibility between drug and carrier. Moreover DSC thermogram of SD and pure drug suggested the change in crystallinity of Cefpodoxime Proxetil. SEM showed that the physical structure of Cefpodoxime Proxetil was modified from crystalline to amorphous. Dissolution rate of Cefpodoxime Proxetil, physical mixture and SD were found 46.3%, 65.04% and 91.04 % respectively Which concluded a significant improvement in in vitro drug release profile. Solid dispersion of Cefpodoxime Proxetil and soluplus prepared in 1:10 ratio by solvent evaporation method resulted in enhancement of aqueous solubility of Cefpodoxime Proxetil and hence improved dissolution.

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