Formulation and Evaluation Of Dispersible Tablets of Cefpodoxime Proxetil | Abstract
Asian Journal of Pharmaceutical Technology and Innovation (ajpti)
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Formulation and Evaluation Of Dispersible Tablets of Cefpodoxime Proxetil
The demand of solid oral drug delivery systems has been growing during the last decade especially for geriatric and pediatric patients because of difficulties in administration through other routes. Hence the present research work is directed towards development of dispersible tablets of cefpodoxime proxetil using direct compression attributed to rapid disintegration of dispersible tablet in water forming a stabilized dispersion.
These tablets were prepared by using crospovidone, sodium starch glycolate and croscarmellose sodium as superdisintegrants in different concentration. Total nine formulations were prepared and evaluated for hardness, friability, weight variation, content uniformity, wetting time, water absorption ratio, disintegration time and in-vitro drug release (all tests were performed as mentioned in the Pharmacopoeia IP or USP). The stability studies were performed as per ICH guidelines. Stability study of final batch showed no significant changes in tablet properties.
F9 formulation was found to be superior as it showed better results than other formulations disintegration time, percentage drug release and dispersion time were 26 seconds, 98.83% and 31.1 seconds respectively. Showing better disintegration time and drug release than other formulation