Formulation and Evaluation of Film Coated Tablet of Rosuvastatin
Abstract
Dhruv Prakash Tiwari*, Manoj kumar Mishra
Rosuvastatin is an antilipidemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. Hypo-lipidemic is a disorder of cholesterol level in a liver. Thus formulating Rosuvastatin into a flim coated dosage form would provide fast relief. The tablets were evaluated for the drug content, weight variation, water absorption ratio, wetting time, in vitro disintegration, hardness, friability, thickness uniformity. The tablets disintegrated in vitro within 37 to 40 seconds complete drug were released from tablet within 30 minutes. The results showed that Rosuvastatin Calcium was successfully formulated into a flim coated dosage form.
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