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Formulation and Evaluation of Multiparticulate Drug Delivery System of Pepsin Enzyme | Abstract

Asian Journal of Pharmaceutical Technology and Innovation (ajpti)

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Formulation and Evaluation of Multiparticulate Drug Delivery System of Pepsin Enzyme

Abstract

Formulation and Evaluation of Multiparticulate Drug Delivery System of Pepsin Enzyme

The aim is to develop multi-particulate drug delivery system for pepsin. Multi-particulate systems offer advantage with respect to predictable and even distribution and transportation through GI track. Multi-particulate system can be prepared by various techniques such as agitation, Powder layering, solution layering. In this study, multi-particulate systems of pepsin have been attempted using Lactose and Guar gum as principal excipients. Suitable dough of pepsin with excipients was prepared and pass through sieve # 8.The extrudets were spheronised using spheronizer. Factorial design was applied using speed (RPM) and time for spheronisation as independent variables at three levels. Formulations were evaluated for particle size, % yield, % entrapment efficiency, Disintegration time and In vitro drug release. Relationship between dependent and independent variables was established using design expert 7.0.0.

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