Formulation and Evaluation of Rizatriptan Benzoate Orodispersible Tablets
M.Vijaya Laxmi*, Dashavarnachary.V, P. Mamatha Rani
Oral disintegrating tablets have emerged as an alternative to the conventional oral dosage forms to improve the patient compliance. Due to problem in swallowing ability with age, the paediatric and geriatric patients complain of difficulty to take conventional solid dosage forms. The ODT’s are solid dosage forms that dissolve or disintegrate rapidly in the oral cavity. This results in solution or suspension without the need of water. The main objective of this work is to formulate and evaluate Rizatriptan Benzoate ODT’s using different concentration of super disintegrating agents like croscarmellose, Sodium Starch Glycolate (SSG), Crospovidone, Yellow potato starch. In this study uses different concentrations of diluents like Spry Dried Lactose, Avicel, Mannitol to optimize diluents concentration. After optimizing diluents concentration the study is continued by using different super disintegrating agents. Tablets were prepared by direct compression method and evaluated for hardness, thickness, friability, disintegration time, and percentage of drug release. The results indicated that formulation prepared with Crospovidone and Avicel: Mannitol (30:70) was found to be optimised which provides maximum drug release(100%) and minimum disintegration time (less than 10 second).
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