Formulation and Evaluation of Transdermal Patches of Antihypertensive Drug
Atif Hussain Halwai*, Shaffi Khurana
Transdermal therapeutic system are defined as self-contained, discrete dosage forms, which when applied to the intact skin, deliver the drug(s), through the skin, at a controlled rate to the systemic circulation so that it can improve the therapeutic efficacy and safety of the drugs. Through a diffusion process the drug enters the bloodstream, directly through the skin. The main disadvantages to transdermal delivery systems stems from the fact that the skin is a very effective barrier, as a result only medications whose molecules are small enough to penetrate the skin can be delivered. The purpose of this study was to develop suitable matrix transdermal therapeutics system of atenolol with different proportions of Ethyl cellulose (EC) and Hydroxy Propyl Methyl cellulose (HPMC). Five formulations were prepared by solvent casting method. The prepared patched showed satisfactory physiochemical characteristics of weight uniformity, thickness, folding endurance, moisture lost, moisture absorption for stability of the formulation and drug content were uniform in all patches. Invitro study done by using Franz diffusion cell having cellophane membrane to determine the amount of drug present in the formulation patch. In different formulation on the basis of evaluation parameters and by optimization study formulation F4 shows satisfactory drug release pattern.
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