Formulation and Evaluation of Transdermal Patches of Metoclopramide Hydrochloride
Abstract
Shinde P. V. *, Shirolkar S. V.
The present research was designed to evaluate matrix type Metoclopramide
hydrochloride transdermal patches. Metoclopramide hydrochloride has an
average oral bioavailability of about 75% but it appears to vary from 30 and
100%. So, the present work is an attempt to study effect of variation in
Methocel E15LV concentration and study effect of hydrophilic and
hydrophobic Methocel E15LV – Eudrgit RL100 combination on release profile
of Metoclopramide Hydrochloride. All prepared formulations were evaluated
for physical and mechanical properties like thickness, moisture uptake,
percent flatness, tensile strength, and percent elongation. An attempt was
made to get a patch with suitable drug release property as well as physical and
mechanical properties. A formulation containing Methocel E15LV 2% has
shown good physical, mechanical and in-vitro drug release properties. It also
showed good diffusion of Metoclopramide hydrochloride across rat skin.
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