GET THE APP

Formulation and Evaluation of Transdermal Patches of Metoclopramide Hydrochloride | Abstract

Asian Journal of Pharmaceutical Technology and Innovation (ajpti)

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Formulation and Evaluation of Transdermal Patches of Metoclopramide Hydrochloride

Abstract

Shinde P. V. *, Shirolkar S. V.

 The present research was designed to evaluate matrix type Metoclopramide

hydrochloride transdermal patches. Metoclopramide hydrochloride has an
average oral bioavailability of about 75% but it appears to vary from 30 and
100%. So, the present work is an attempt to study effect of variation in
Methocel E15LV concentration and study effect of hydrophilic and
hydrophobic Methocel E15LV – Eudrgit RL100 combination on release profile
of Metoclopramide Hydrochloride. All prepared formulations were evaluated
for physical and mechanical properties like thickness, moisture uptake,
percent flatness, tensile strength, and percent elongation. An attempt was
made to get a patch with suitable drug release property as well as physical and
mechanical properties. A formulation containing Methocel E15LV 2% has
shown good physical, mechanical and in-vitro drug release properties. It also
showed good diffusion of Metoclopramide hydrochloride across rat skin.

Share this article

tempobet

tempobet giriş

tempobet giriş

paper.io

agar io

wowcappadocia.com cappadocia tours
cappadocia-hotels.com cappadocia hotels
caruscappadocia.com cappadocia hotel
brothersballoon.com cappadocia balloon
balloon-rides.net cappadocia balloon flights

wormax io