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Formulation and Evaluation of BuccalFilms of Ranitidine Hydrochloride

Abstract

Harish Goyal*, Sameer Rastogi, Vandana Arora, Vijay Bhalla

Buccal drug delivery system is been considered as a potential non invasive route of drug administration with several advantages viz prolonged therapeutic effect dose reduction improved bioavailability lesser side effects than conventional dosage forms etc. The present investigation involves formulation evaluation and comparison of formulated polymeric buccal patches using ranitidine HCL as model drug the formulations were prepared by solvent evaporation / casting method. The prepared buccal patches were evaluated for thickness, drug content uniformity, weight variation, folding endurance, swelling index, surface pH, surface morphology, in-vitro & ex-vitro drug release.In-vitro release studies were performed across cellophane membrane using Franz Diffusion Cell (FDC). The surface morphology of the patch was examined by Scanning Electron microscopy (SEM). Based on the physicochemical and in-vitro release study, formulation F3, F4 and F5 were chosen for further ex-vivo release studied. Ex- vivo permeation studied were carried out through buccal mucosa of pig using FDC. Drug release data were fitted to various pharmacokinetic model equations such as zero order kinetics, first order kinetics, Higuchi’s and korsmeyerPeppas model in order to find out mechanism of drug release.

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