Formulation and Evaluation of Curcumin Loaded Gastro-Retentive Multi particulate Drug Delivery System
Gopalsingh Devda, Shreeraj Shah2, Shital Trivedi3
To develop and optimize a multiparticulate gastro-retentive floating dosage form of Curcumin with targeted and sustained release characteristics. Curcumin give protective effect against Inflammation and Cancer but the physicochemical properties of the molecules leads to poor solubility and stability. Aqueous solubility was enhanced by complex formation with Hydroxypropyl β-Cyclodextrin (HP β-CD). This complex with enhanced solubility profile was further used to prepare multiparticulate floating pellets. Floating pellets of Curcumin HP β-CD complex were prepared by Extrusion-Spheronization technique using Hydroxypropyl methylcellulose (HPMC K100 M) as low density controlled release polymer, Ethyl cellulose as a release retardant polymer and Sodium bicarbonate as a gas generating agent. The formulations were evaluated for In vitro Drug release, Buoyancy and Surface morphology study. The investigation revealed that floating pellets of Batch B3 possessed optimum formulation characteristics. The drug release from pellets was Non fickian and sufficiently sustained for 12 hr. This study indicates that multiparticulate gastro-retentive floating dosage form of Curcumin HP β-CD complex with sustained release characteristics can be safely and effectively used to treat Gastric cancer.
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