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Formulation and In-Vitro Evaluation of Modified Release Delivery of Trazodone Hydrochloride Tablets | Abstract

Asian Journal of Pharmaceutical Technology and Innovation (ajpti)

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Formulation and In-Vitro Evaluation of Modified Release Delivery of Trazodone Hydrochloride Tablets

Abstract

R. S. Pentewar1, Rohit Udhav Bharti1, Kiran Suryawanshi2, R.V. Sugave

The objective behind this study was to formulate and evaluate Modified release tablet of Trazodone hydrochloride by using different hydrophilic and hydrophobic polymers by Wet granulation technology and to study the effect of different concentrations of polymers on release rate from tablet. Tablets were prepared using carnauba wax as extra fine powder (8.5-28%), hydroxypropyl methylcellulose (HPMC) (2-14.5%), and polyvinyl pyrollidone (PVP K-30) (8.5-30%) as release retardant polymers. The FTIR and DSC analysis does not show any interaction of drug with Excipients. The formulation was optimized on the basis of acceptable pre and post compressional parameters and in-vitro drug release. The resulting formulations produced monolithic tablets with optimum hardness, consistent weight uniformity and low friability. The results of dissolution studies indicated that Batch F8 exhibited drug release of 99% at the end of 12h to provide sufficient concentration for achieving satisfactory therapeutic value for extended period of time. The drug release from Batch F8 formulation was sustained up to 12 h. Fitting in-vitro drug release data from optimized matrix formulation to first order followed by Korsmeyer’s-Peppas indicated that diffusion could be mechanism of drug release.

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