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Formulation, Development and Characterization of Chronotherapeutic Time Released Press Coated Nizatidine Tablets | Abstract

Asian Journal of Pharmaceutical Technology and Innovation (ajpti)

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Formulation, Development and Characterization of Chronotherapeutic Time Released Press Coated Nizatidine Tablets

Abstract

Pavan Nathu Patil*, Dr. Dhananjay M. Patil, Dr. Vinod A. Bairagi

The aim of present study was to develop and characterize pulsatile release tablets of Nizatidine, H2 antagonist, for effective treatment of Peptic ulcer. The pulsatile tablets prepared by compression coating method consisted of two different parts: a core tablet, containing the active ingredient and an erodible outer coating layer of polymer. The rapid release core tablets were prepared by using superdisintegrant along with active ingredient. Compression coating of optimized core tablets was done by using HPMC K100M and Ethyl Cellulose. The effect of formulation composition on the barrier layer comprising both polymers, excipients on the lag time of drug release was investigated. The Core tablets and press coated tablets were evaluated for weight variation test, thickness, hardness, friability, Disintegration, lag time and dissolution study. An increase in lag time was observed with the increasing concentration in each case. Formulation F4 containing HPMC K100M and Ethyl Cellulose was found to provide desired lag time, drug release profile, better integrity among all formulations and thus, compliant with the chronotherapeutic objective of Peptic Ulcer.

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