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Formulation, Development and Evaluation of Fast Dissolving Film of an Antihypertensive Drug | Abstract

Asian Journal of Pharmaceutical Technology and Innovation (ajpti)

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Formulation, Development and Evaluation of Fast Dissolving Film of an Antihypertensive Drug

Abstract

Bhagat B.V.*, Hapse S. A., Darkunde S. L., Autade Y. P.

Hypertension is a major cause of concern not just in the elderly but also in the youngsters. An effort was made to formulate a fast dissolving film(FDF) containing Indipamide which is used in the treatment of hypertension with a view to improve the onset of action, therapeutic efficacy, patient compliance and convenience. The major challenge in formulation of oral films of Indipamide is that it shows very less solubility in the pH range of 3–9. Various film forming agents and polyhydric alcohols were evaluated for optimizing composition of fast dissolving films. Fast dissolving films were formulated using solvent casting method. Optimized formulations were evaluated for their weight, thickness, folding endurance, appearance, tensile strength, and disintegration time and dissolution profile.

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