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Formulation Development and in vitro Evaluation of Sustained Release Tablets of Telmisartan by Solid Dispersion Technology | Abstract

Asian Journal of Pharmaceutical Technology and Innovation (ajpti)

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Formulation Development and in vitro Evaluation of Sustained Release Tablets of Telmisartan by Solid Dispersion Technology

Abstract

Ganesh R. Godge* Varsha D. Palwe, Pratap Y. Pawar

In the present work ,an attempt was made to formulate sustained release tablets of Telmisartan by solid dispersion technique for improving solubility Telmisartan using PEG 4000 and PVP K30.The Telmisartan tablets were prepared by wet granulation method using HPMC K4M as sustained release polymer in different concentrations .The prepared tablets were evaluated for various physiochemical parameters, In vitro Drug release study was carried out in phosphate Buffer PH 6.8using USP TYPE II paddle apparatus. Increase in HPMC concentrations resulted in a significant decrease in Telmisartan release .tablets containing 75 mg of HPMC K4M (f1and f4) shows 78% and 70% drug release upto 9 hr. Tablet containing 90 mg of HPMC K4M (f2and f5) shows 80 % and 81%drug release upto 9 hr. and tablet containing 105 mg HPMC K 4M (f3 and f6)shows highest drug release 91%and83% compared to other formulations. the in vitro data is fitted in to different kinetic models like zero order ,first order, korsmeyer and matrix plot. From this study, it was clarified that solid dispersion technique was one of the promising sustained release system applying for the poorly water soluble drugs

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