In Vitro Evaluation of Anticancer Activity of Methnaolic Extract of borassus Flabellifer linn. Leaves on Different Human Cancer Cell Lines
Ashok P. Gingine1*, Tukaram M. Kalyankar3, S. V. Mandge 2, Prasad G. Jamkhande3
Identification of new anticancer medicinedevoidof life threatening side effects as that of synthetic anticancer drug is the need of today’s cancer treatment. Ayurveda, the Indian traditional system of medicine is based on plant as a source of medicine. Medicinal plants such as Picrorhiza KurroaRoyle ex Benth., Cetrus deodaraRoxband herbal formulations like Triphala ghrita, Sthauneyaka and Madhusnuhi rasayana are mentioned in the Ayurveda for the treatment of tumour. Plants ofBorrasus family are well known fortheir medicinal and nutritional values.Borassus flabellifer Linn. is traditionally important medicinal plant and is widely distributed in India.The methanolic extractof Borassus flabellifer Linn.was screened against colon cancer (HCT15), Human lung cancer (Hop65) and Human hepatoma (HEPG2) cell lines using SulforhodamineB (SRB) assay. Adriamycin was used as a standard to compare the results of methanolic leaves extract of Borassus flabellifer Linn.The findings revealed that extract do not inhibit growth of these cell lines with no potential anticancer effects. These results indicate that methanolic extract of Borassus flabellifer Linn.is not effective against these cancer cell lines. However, further studies are needed to test extract against other cancer cell lines to reveal its anticancer effect.
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