In vivo Targeting of Liposomally complexed DNA Vaccines to Dendritic Cells induce Long Lasting Protection against Melanoma Tumor
Gopi Krishna Moku
Background: Since Dendritic cells (DCs) are responsible for both in the instigation of adaptive immune response and the tolerance initiation, manipulation of DCs with DNA vaccines in vivo encoding tumor-associated antigens is considered as an efficient approach to combat cancer .
Objective: Developing a simple & economical in vivo DCs targeting delivery system as well as achieving long-lasting immunity which is a substantial scientific task in DNA vaccination .
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