Metabolic Control Improves Baroreflex Sensitivity In Diabetic Rats
Abstract
Farah Khaliq1*, Adila Parveen2, M Fahim2
Objectives: The present study was undertaken to evaluate the
effect of glycemic control on the baroreflex sensitivity, in rats
having uncontrolled diabetes.
Methods: Diabetes was induced in healthy male Wistar albino rats
by a single intraperitonial injection of Streptozotocin (STZ).
Experiments were conducted eight weeks after induction of
diabetes. The baroreflex was evaluated by measuring the changes in
heart rate (HR) with changes in arterial blood pressure induced by
bolus injections of phenylephrine (vasoconstrictor) and sodium
nitroprusside (vasodilator).
Results: After 8 weeks of STZ administration the reflex bradycardia
and tachycardia response to hypertension and hypotension
respectively were impaired in the diabetic group but improved after
one month of Insulin therapy. The decreased body weight, heart
rate and blood pressure and raised blood sugar in diabetic rats
were improved by Insulin therapy. Insulin significantly reduced
oxidative stress and inflammatory cytokine levels in diabetic rats.
Conclusions: Results suggest that glycemic control with Insulin
improves the altered baroreflex sensitivity in diabetic rats possibly
through maintaining endogenous antioxidant enzyme activities and
decreasing cytokine levels.
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