Metabolic Control Improves Baroreflex Sensitivity In Diabetic Rats | Abstract

Asian Journal of Pharmaceutical Technology and Innovation (ajpti)

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Metabolic Control Improves Baroreflex Sensitivity In Diabetic Rats


Farah Khaliq1*, Adila Parveen2, M Fahim2

 Objectives: The present study was undertaken to evaluate the

effect of glycemic control on the baroreflex sensitivity, in rats
having uncontrolled diabetes.
Methods: Diabetes was induced in healthy male Wistar albino rats
by a single intraperitonial injection of Streptozotocin (STZ).
Experiments were conducted eight weeks after induction of
diabetes. The baroreflex was evaluated by measuring the changes in
heart rate (HR) with changes in arterial blood pressure induced by
bolus injections of phenylephrine (vasoconstrictor) and sodium
nitroprusside (vasodilator).
Results: After 8 weeks of STZ administration the reflex bradycardia
and tachycardia response to hypertension and hypotension
respectively were impaired in the diabetic group but improved after
one month of Insulin therapy. The decreased body weight, heart
rate and blood pressure and raised blood sugar in diabetic rats
were improved by Insulin therapy. Insulin significantly reduced
oxidative stress and inflammatory cytokine levels in diabetic rats.
Conclusions: Results suggest that glycemic control with Insulin
improves the altered baroreflex sensitivity in diabetic rats possibly
through maintaining endogenous antioxidant enzyme activities and
decreasing cytokine levels.

Share this article


tempobet giriş

tempobet giriş

agar io cappadocia tours cappadocia hotels cappadocia hotel cappadocia balloon cappadocia balloon flights

wormax io