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Method Development and Validation of Cetirizine hydrochloride, Phenylephrine hydrochloride and Nimesulide by UV and HPLC | Abstract

Asian Journal of Pharmaceutical Technology and Innovation (ajpti)

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Method Development and Validation of Cetirizine hydrochloride, Phenylephrine hydrochloride and Nimesulide by UV and HPLC

Abstract

Vilas Arsul*1, Ashok Kagane1, Supriya Wagh2

Phenylephrine HCL, Cetirizine HCL and Nimesulide, one of the most commonly prescribed Nasal decongestant, Antihistamine and Nonsteroidal anti-inflammatory respectively, In this regard, the research and development of reliable analytical methods for self-determination. It is freely soluble in water, methanol and acetonitrile. Insoluble in acetone. The main aim of present Research work is to develop and validate a method for estimation of Cetirizine HCL, Phenylephrine HCL & Nimesulide by the using of UV visible spectrophotometry and High Performance Liquid Chromatography. Double beam UV –visible spectrophotometer with 10 mm matched quartz cell (Shimadzu -1700) one is sample and other is reference were use for quantitative estimation of Phenylephrine HCL, Cetirizine HCL and Nimesulide. The various trials were carried out by varying parameters. RP-HPLC method for estimation of pharmaceutical dosage form was developed successfully. Chromatographic separation was performed on Phenomenex Gemini C18 stainless steel column with dimension 250 × 4.6 mm, 5 μm particle size. The mobile phase consisting of a acetonitrile : water (ph3) 60:40 v/v) was delivered at rate of 1 ml/min. The detection was made at 229 nm. Mobile phase was filtered through a 0.45 μ membrane filter paper and degassed before analysis. Separation was performed at ambient temperature.

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