Asian Journal of Pharmaceutical Technology and Innovation (ajpti)

Monitoring of Oxidative Stress in Alcoholic Liver Disease

Abstract

Chandra Kishore Prasad*, Jyotish Chandra Pandey

The close association between oxidative stress and lifestyle-related diseases has become well known. Chronic consumption of alcoholic beverages is a primary cause of liver injury. Oxidative stress has been considered as a conjoint pathological mechanism, and it contributes to initiation and progression of liver injury. A study was carried out in 30 cirrhotic patients with chronic alcoholism of 30-55 years of age. The blood samples were collected for the estimation of the biochemical factors. The serum obtained from samples was subjected to estimation of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Plasma Malondialdehyde (MDA) and Gamma Glutamyl transferase. The level of the ALT, AST, MDA & GGT were significantly found increased in alcoholic liver diseases patients when compared to normal patients. This concludes that increased oxidative stress and compromised antioxidant defence system in alcoholic liver diseases patients.

Share this article