Optimization of Formulation of Gastroretentive Drug Delivery System Containing Atenelol
A. H. Attar*, Mr. V. D. Havaldar
Floating dosage form is an oral dosage form that is designed to prolong the residence time of dosage form within the GI tract. It is formulation of a drug and gel forming hydrocolloids meant to remain buoyant on stomach contents. The purpose of this investigation was to optimize the formulation of gastroretentive drug delivery system of Atenelol. Atenelol is a drug of choice for the treatment of hypertension and it is a ß-1 cardio selective adrenergic receptor blocker. Optimization of formulation of floating tablets of Atenelol was done depending upon three different factors such as controlled drug release of drug, floating characteristics and hardness of tablets. This was carried out by studying the effect of different proportions of the polymers, effervescent and different compression pressure. Semi-synthetic polymers HPMC-K100M and a natural polymer, Xanthan gum were used to assess the effect on the release of drug. Dicalcium phosphate was used as a channeling agent. Sodium bicarbonate was used as a gas generating agent. Evaluation of powder blends like angle of repose, bulk density, Carr’s index and Hausner’s ratio was evaluated. Atenelol floating tablets were evaluated for In vitro dissolution and floating lag time. Evaluation of tablets i.e. diameter, thickness, friability, hardness, average weight and content uniformity were performed. Drug release from the tablets was sufficiently sustained.
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