Phytosomes: An Emerging Nanotechnology For Improved Bioavailability of Phytomedicines ��? A Review
Abstract
Amudha S1, Prabal Kumar Manna2, Jeganathan N S3, Anbazhagan S4
Novel complexation technique named as `phytosome’ plays an important role to facilitate absorption and improve bioavailability. The delivery of phytomedicine is always challenging due to poor aqueous solubility, poor permeation, low systemic availability and extensive first pass metabolism. Drug molecules from natural sources and dietary soy phospholipids are complexed and generated cell like structures called phytosomes. Phytosome act as a bridge between novel delivery system and conventional delivery system and has effectively enhanced the bioavailability of many popular herbal extracts including milk thistle, Ginko biloba, grape seed, green tea, hawthorn, Ginseng etc and can be developed for various therapeutic uses or as dietary supplements. Current review highlights recent information, on commercial preparation of phytosomes as well as the various other novel approaches for delivery of herbal constituents.
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