Radiographic study to evaluate the effect of Acetaminophen injection on orthodontic tooth movement in rats.
Abstract
Maher Al Ajami*, Feras Baba and Mohamad Yaser Abajy
To evaluate the effect of acetaminophen injection as an analgesic accompanying orthodontic treatment on reducing root resorption resulting from the application of a large orthodontic force when injected during orthodontic treatment in rats. The sample consisted of 10 WISTER rats from the group of rats present in the animal house at the Faculty of Pharmacy-University of Aleppo. The rats were old for two to six months and weighed between 200-250 grams. A closing orthodontic spring made of nickel-titanium with a strength of 100 grams was applied between the upper first molar and incisor in the right and left sides of the upper jaw of the rat for a period of thirty days, and acetaminophen was injected into the right side in the gingival region closest to the upper first molar, A three-dimensional radiograph was taken before applying the orthodontic force and immediately after its removal, The distance was measured between the mesial surface of the upper second molar and the distal surface of the upper first molar in the same side. Acetaminophen injections did not have an inhibitory effect on orthodontic tooth movement like other steroidal and non-steroidal anti-inflammatory drugs.
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