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Sachet Formulation of Taste Masked Antibiotic Drug For Pediatrics Use | Abstract

Asian Journal of Pharmaceutical Technology and Innovation (ajpti)

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Sachet Formulation of Taste Masked Antibiotic Drug For Pediatrics Use

Abstract

Shubhangi V. Shekade*, S. V. Shirolkar, S. S. Poddar, Vasant Shetty

The major problem of bitter drug is to restrict greatly the further development of oral preparations and clinical application of these drugs. The current study was aimed to prepare taste masked granules by using fluidized bed processor (Miniquest F). In this study ciprofloxacin HCl along with HPMC (6cps), Aspartame (6%) and flavour (0.6%) was granulated and passed through sieve no.30# to get optimized size of granules. The key variables were identified as spray rate, inlet temp, atomization air pressure & air flow in fluidized bed processor to obtain required size of granules. Air flow range for the process was decided on the basis of fluidization of API (0.7-0.9 bar) used. Ciprofloxacin being a poorly fluidized drug air flow was kept at 0.7-0.9 bar. The obtained granules were coated with different taste masking polymers vizEudragit EPO (70%) &Eudragit L100 (40%&30%). Complete taste masking was observed with Eudragit L100 (40%). The coated granules were then evaluated for its micromeritic properties, taste masking &in-vitro dissolution. The coated ciprofloxacin granules were filled in a sachet manually along with other excipients to make a unit dose weight of 1 gm.

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