Serum Heavy Metal Study In Female Wistar Rats Administered With Counterfeit Neurobion | Abstract

Asian Journal of Pharmaceutical Technology and Innovation (ajpti)

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Serum Heavy Metal Study In Female Wistar Rats Administered With Counterfeit Neurobion


Ayobola A Iyanda1; Dapo P Oparinde1

Purpose: While trace elements are known for the very important role they play as cofactors of diverse biochemical reactions, heavy metal on the other hand have been recognized for their toxic effects and the fact they do not carry out any meaningful role that is beneficial to a living mammalian system. Yet exposure has been reported through different sources, exposure through fake drug administration being one of them. The aim of the present study is to determine the serum levels of Cd, Pb, Al, Si, Hg, Ni, and As in 12-14 weeks old female Wistar rats administered with fake neurobion tablets at 30 mg/kg level. Method: Twelve of the eighteen rats used for the study were divided equally into 2 groups and administered with either 30 mg/kg BW fake neurobion or genuine products. Six other rats served as the control. Route of administration was by gastric gavage and blood was obtained through retro-orbital bleeding. Serum levels of arsenic, cadmium, aluminum, silicon, lead, mercury, and nickel were estimated by the atomic absorption spectrometric method. Statistical analysis was carried out on data obtained using analysis of variance (ANOVA). Differences were considered significant at p ≤ 0.05. Results: Of all the heavy metals assessed, none was significantly different. Conclusion: The results of the study suggest that the absence of the heavy metals in the fake neurobion used for the present study.

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