Stability Indicating UV Spectrophotometric Assay Method Development for Simultaneous Determination of Ranitidine and Dicyclomine in Bulk and Pharmaceutical Dosage Form
Abstract
Stability Indicating UV Spectrophotometric Assay Method Development for Simultaneous Determination of Ranitidine and Dicyclomine in Bulk and Pharmaceutical Dosage Form
A simple, accurate, economic and reproducible ultraviolet spectrophotometric method for the simultaneous estimation of ranitidine and dicyclomine has been developed and validated. The method was involved the measurement of absorbance at two wavelengths 325 nm and 218 nm for ranitidine and dicyclomine respectively by using methanol as solvent. The method was found to be linear in the range of 3-18 μg/ml for ranitidine and 1-6 μg/ml for dicyclomine respectively. The method was validated in terms of linearity, accuracy, precision, limit of detection and limit of quantitation as per ICH guidelines. The method has good reproducibility with % RSD less than two. Thus, proposed method can be successfully applied for ranitidine and dicyclomine in routine analysis work.
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