GET THE APP

Study of Neusiln UFL2 and ?²-Cyclodexrtin as Solid Carriers in Solid Self-Microemulsifying Drug Delivery System of Atorvastatin Calcium Prepared by Spray Drying | Abstract

Asian Journal of Pharmaceutical Technology and Innovation (ajpti)

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Study of Neusiln UFL2 and ?²-Cyclodexrtin as Solid Carriers in Solid Self-Microemulsifying Drug Delivery System of Atorvastatin Calcium Prepared by Spray Drying

Abstract

Bharat V. Jadhav*, Vikas B. Gawali, Sandip G. Badadhe, Mahesh D. Bhalsing

The main objectives of this work was, to study the effect of β-cyclodextrin and Neusilin UFL2 as a hydrophilic and a hydrophobic solid carrier respectively in solidification of self-microemulsifying drug delivery system prepared by spray drying technique. The liquid SMEDDS consisted of poorly water-soluble drug Atorvastatin calcium (10mg), and Capmul MCM (200mg) and Tween 20 (800mg) as oil and surfactant respectively. This formulation was spray dried by using the solid carrier in various formulations to carrier ratio. These spray dried formulation were characterized for flow properties, drug content, reconstitution and solid state properties. In-vitro dissolution test was carried out to observe the effect of solidification on release of drug and compare it with liquid SMEDDS and marketed formulation. The liquid SMEDDS to solid carrier ratio of 1:0.5 showed passable flow properties and high drug content. DSC, PXRD revealed that the drug in the solid SMEDDS was disperse in amorphous form while SEM results indicated that the particle formed were spherical with liquid formulation loading. In-vitro drug dissolution study indicated that after solidification the drug release was enhanced as compared to plain drug and marketed formulation. After three month stability study solid SMEDDS did not show any drug precipitation as well as phase separation. Thus it can be concluded that the solidification of liquid SMEDDS using these carrier retain the original performance with enhance stability.

Share this article

tempobet

tempobet giriş

tempobet giriş

paper.io

agar io

wowcappadocia.com cappadocia tours
cappadocia-hotels.com cappadocia hotels
caruscappadocia.com cappadocia hotel
brothersballoon.com cappadocia balloon
balloon-rides.net cappadocia balloon flights

wormax io