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Zidovudine: A Review of Analytical Methods

Abstract

Ashish S. Patil1*, Gaurav Patil2

Zidovudine (AZT) is a NRTI type of antiretroviral drug used for the treatment of human immunodeficiency virus (HIV) infection / acquired immunodeficiency syndrome (AIDS), metabolized in lever. It is an analog of thymidine. It not easy to get whole data of zidovudine within a short time, it was reported that it mostly prescribed used in combination with other agents in the therapy and prophylaxis of HIV infection and the AIDS. This article provides published analytical methods reported so far in the literature for the determination of AZT in bulk drug, pharmaceutical formulation and biological samples. In that they include various techniques like spectroscopic chromatographic methods like RPHPLC, HPTLC, LC-MS, LC-MS/MS and electroanalytical methods.

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