Formulation And Evaluation of Medicated Chewing Gum Containing Caffeine Salicylate
A. H. Attar*, Dr. S. P. Gawade
Caffeine salicylate shows more CNS stimulant activity than caffeine along with mild analgesic and anti-inflammatory actions. Caffeine salicylate was synthesized in Pharmaceutical Chemistry Laboratory, Satara College of Pharmacy, Satara. Chewing gum formulation was prepared in tablet form by using direct compression method. Lecithin was used as an emulisifier and sorbitol as a softner and synthetic gum base along with other excipients. Nine different formulations were prepared by changing the concentration of emulsifier and softner. Evaluation of tablets i.e. diameter, thickness, friability, hardness, average weight, content uniformity, stickiness and dissolution study were performed. A 32 full factorial design was selected and the 2 factors were evaluated at 3 levels. The amount of sorbitol (X1) and lecithin (X2) were selected as independent variables and the dependent variables were hardness and percent drug release at 30 min (%DR30min). The data obtained was treated using Stat-Ease Design Expert 184.108.40.206 software and analyzed statistically using analysis of variance (ANOVA).
Share this article