Noreen Zaman
Pharmaceutical and Preclinical Sciences, Vertex Pharmaceuticals Incorporated, Boston, MA 02210, USAPublications
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Research Article
Mechanical Characterization of Extracellular Matrix Hydrogels: Comparison of Properties Measured by Rheometer and Texture Analyzer
Author(s): Taraka Sai Pavan Grandhi, Noreen Zaman, Alamelu Banda, Varsha Dhamankar, Cathy Chu, Emily Perotta and Irina Kadiyala*
Extracellular matrix (ECM) hydrogels have shown remarkable benefit as new materials for regenerative medicine for multiple applications. However, for ECM-based materials to be used in vivo, they must possess appropriate mechanical properties to enable handling during storage and administration, as well as properties to induce the needed biological responses. The experiments carried out in this study allowed deeper understanding of the physical characteristics of gels towards their use in a clinical setting and subsequent commercialization. Using rheometer and texture analyzer, we expanded the previously reported mechanical characterization of ECM gels and here we present data on the new tests such as constant shear at different temperatures; cross-over temperature/gel point; cohesivity, adhesivity and hardness; fitting to Burger’s model; and strain-s.. Read More»