Formulation of an Optimised Glimepiride Compression Coated Tablets for Chronotherapeutic Drug Delivery
Background: Chronopharmaceutics is an aspect of pharmaceutics devoted to the formulation of drug delivery systems that release their active ingredients at a rhythm that ideally matches the physiological requirement of a particular disease condition. Objective: The aim of the present study is to formulate an optimized coated glimepiride time release tablets (CGTRT) containing glimepiride, a third generation sulphonylurea in the inner core for chronotherapeutic drug delivery system. Method: Glimepiride core tablets (GCT) containing Anacardium occidentale gum (10 %w/w) as binder and maize starch as disintegrant (10 %w/w) were prepared at compression pressure of 30 unit on the arbitrary load scale. CGTRT containing Anacardium occidentale gum powder with sodium starch glycolate at varying concentration (0.5%, 1%, 2%, 4%, and 6%w/w) were also prepared at 30 unit on the arbitrary load scale. The parameters determined were hardness, friability, drug content, disintegration time and in vitro drug release profile. Result: The hardness value of the core tablet and market formulation was > 4.1 Kpa while their friability values were 1.7% (core) and 1.2% (market formulation). The core tablet and market formulation disintegrated in 7min and 6min respectively, while their drug content was > 97%. The hardness and friability values of the CGTRT were > 12 KPa and < 0.59% respectively. All CGTRT displayed different lag time and this was dependent on the concentration of the sodium starch glycolate incorporated into the CGTRT. The drug content of the formulations was > 94%. Conclusion: CGTRT1 with a lag time of 6 h before release of glimepiride was taken as the optimized formulation..
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