Patipat Kamdenlek
Department of Biochemistry, Faculty of Medicine, Chiang Mai University, ThailandPublications
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Research Article
Proteomic analysis to determine mechanism of purple rice bran on pancreatic damage of type 2 diabetic rats
Author(s): Ei Ei Hlaing, Supicha Rungjarernarreejitt, Puriwat Fakfum, Patipat Kamdenlek and Pichapat Piamrojanaphat*
Diabetes is one of the most common metabolic diseases all over the world. Type 2 diabetic contributes nearly 90% of diabetic patients. Type 2 diabetes is characterized by hyperglycemia with dysfunction of pancreatic beta cells and insulin resistance. Anthocyanins are the major functional component in purple rice (Oryza sativa L. indica). Our previous studies showed that supplementation of purple rice husk attenuated hyperglycemia and prevented pancreatic damage. However, the molecular mechanism of anti-diabetes activities of purple rice need more investigated. In this study, pancreatic tissue samples of type 2 diabetic rats with or without purple rice bran supplement were studied through proteomic approach. Five unique proteins were found in purple rice bran supplemented diabetic rats (Rasgrp3, Clca 1, Olr3, Abcc4, Mfn1). These 5 proteins interacted with o.. Read More»